FLUXIMINE PASTE

DESCRIPTION
A clear, homogeneous, colourless, smooth, almost odourless paste.  Each gram contains Flunixin 50mg (as Flunixin meglumine).  Each syringe contains 1500mg of Flunixin.

MODE OF ACTION
The active constituent Flunixin is a potent non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, and analgesic action. Flunixin is rapidly absorbed from the gastrointestinal tract after oral administration, (80% bioavailability) with peak plasma levels being reached in approximately 30 - 40 minutes. Onset of therapeutic effect is slower than the injectable form, although it usually occurs within 2 hours, with peak response within 15 hours and duration of effect up to 30 hours. Flunixin prevents the formation of prostaglandins (PGs) from the precursor arachidonic acid by blocking the action of the enzyme cyclo-oxygenase (prostaglandin synthetase).

INDICATIONS
For the treatment of inflammation and pain associated with musculoskeletal disorders, such as arthritis, laminitis, tendonitis and myositis, in horses.

CONTRAINDICATIONS
Do not exceed recommended dose rate or duration of treatment.
Do not administer to animals still under the effects of general anaesthesia.
Do not use in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastrointestinal ulceration or bleeding, or where there is evidence of blood dyscrasia or hypersensitivity to the product.
Do not administer concurrently with any animal remedy that is potentially nephrotoxic especially if the animal is dehydrated or hypotensive.

DIRECTIONS FOR USE
FOR ORAL USE ONLY
The recommended dose is 1g / 45kg bodyweight, equivalent to 1.1mg/kg bodyweight, once daily for up to five days. The plunger of the dial-a-dose syringe is calibrated in 2g (90kg bwt) increments. Turn the syringe dial to the appropriate mark to deliver the correct dose.
Each syringe is sufficient to treat one 450 kg horse once daily for three days.
Insert the nozzle of the syringe carefully through the interdental space and deposit the required amount of paste on the back of the tongue.
Treatment may be given initially by intravenous or intramuscular injection of Fluximine Injection (ACVM No. A7804) and then followed by Fluximine Paste.

SIDE EFFECTS
Gastric irritation and ulceration may occur if dose rate and/or duration of treatment is increased over recommended levels.

PRECAUTIONS
Monitor drug capability when any other concomitant therapy is needed.
Include appropriate antimicrobial therapy when treating inflammatory conditions that are likely to be associated with bacterial infection.
The effect of Fluximine Paste on pregnant mares has not been determined, therefore its use in pregnant mares should only be undertaken where the expected benefits will outweigh the potential risks.
Take special precautions when administering to aged horses & foals, especially when under 6 weeks of age.

Prescription Animal Remedy (P.A.R) Class I.  For use only under the authority or prescription of a veterinarian.
Registered pursuant to the ACVM Act 1997 No. A9254